NCI Guidelines on the Use of IMRT in Clinical Trials

In 2002, the NCI convened a group of experts to address the issue of using Intensity Modulated Radiation Therapy (IMRT) in clinical trials. At that time, guidelines were established to ensure the safety and comparability of these radiation treatments.

In January, 2005, the NCI updated its guidelines for using IMRT in clinical trials, reiterating the requirements for a multi-element quality assurance program while also allowing IMRT for intra-thoracic tumors with appropriate corrections for tissue heterogeneity and target motion.

The NCI guidelines (see links below) were revised again in July 2006 with the help of the Advanced Technology Consortium (ATC). These guidelines now include criteria for immobilization and imaging to reduce motion artifacts and recognize the variability of dose algorithms for heterogeneity correction.